Leber hereditary optic neuropathy
Zuletzt aktualisiert 8 Sept 2020
Erfüllt die redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen
- Language
- Diskussion
- Audio-Version
- Zu bevorzugten Quellen bei Google hinzufügen
Leber hereditary optic neuropathy (LHON) is an inherited form of vision loss. Although this condition usually begins in a person's teens or twenties, rare cases may appear in early childhood or later in adulthood. For unknown reasons, males are affected much more often than females.
Beschreibung
Leber hereditary optic neuropathy (LHON) is an inherited form of vision loss. Although this condition usually begins in a person's teens or twenties, rare cases may appear in early childhood or later in adulthood. For unknown reasons, males are affected much more often than females.
Blurring and clouding of vision are usually the first symptoms of LHON. These vision problems may begin in one eye or simultaneously in both eyes; if vision loss starts in one eye, the other eye is usually affected within several weeks or months. Over time, vision in both eyes worsens with a severe loss of sharpness (visual acuity) and colour vision. This condition mainly affects central vision, which is needed for detailed tasks such as reading, driving, and recognizing faces. Vision loss results from the death of cells in the nerve that relays visual information from the eyes to the brain (the optic nerve). Although central vision gradually improves in a small percentage of cases, in most cases the vision loss is profound and permanent.
Vision loss is typically the only symptom of LHON; however, some families with additional signs and symptoms have been reported. In these individuals, the condition is described as "LHON plus." In addition to vision loss, the features of LHON plus can include movement disorders, tremors, and abnormalities of the electrical signals that control the heartbeat (cardiac conduction defects). Some affected individuals develop features similar to multiple sclerosis, which is a chronic disorder characterised by muscle weakness, poor coordination, numbness, and a variety of other health problems.
Inheritance patterns
The source lists the following possible inheritance patterns: mitochondrial. More than one pattern can apply in different cases.
Related genes
Other names
Hereditary optic neuroretinopathy
Leber hereditary optic atrophy
Leber optic atrophy
Lebersche hereditäre Optikusneuropathie
Leber's optic atrophy
Leber's optic neuropathy
LHON
Related patient information and medicines
Patient information leaflet
Vorteile des Rauchstopps
If you stop smoking you: Reduce the risk of getting serious smoking-related diseases such as h... Reduce the risk of getting various other conditions which, although not life-threatening, can cause unpleasant problems. For example: Erection problems ( impotence ). Fertility problems. Optic neuropathy - this is a condition affecting the nerve.
Patient information leaflet
Sehprobleme
Most people are concerned when they develop problems affecting their eyes, particularly if this affects their ability ... This leaflet describes most eye conditions which can affect vision, either temporarily or permanently. Nerve signals pass from these "seeing" cells in the retina down nerve fibres in the optic nerve to the area of the brain.
Patient information leaflet
Prolaktinom
A prolactinoma occurs when some of the cells in the pituitary gland (the ones producing prolactin) multiply more than usual to form a small growth (tumour) in the pituitary gland. The prolactinoma makes too much prolactin and this can cause symptoms. Prolactinomas are usually very small. Small prolactinomas (less than 1 cm ) are called.
Patient information leaflet
Hyperopie
Long-sighted people may have difficulty with depth perception (3-dimensional vision), as this needs two eyes to work tog... What causes hypermetropia. The causes of hypermetropia (long sight) are usually hereditary (genetic). Long sight can occur at any age but it tends to become more noticeable above the age of 40 years. In rare cases, long sight.
Patient information leaflet
Sturzprävention bei älteren Menschen
Alcohol: apart from the fact that alcohol can make you drowsy and clumsy, it can also cause long-term medical problems that make falls more likely. These include peripheral neuropathy. This is a condition of Arztpraxis nerves that can cause numbness und pins und needles of the feet or problems mit balance sensation. A disorder of the brain (.
Patient information leaflet
Rauchen
Cigarette smoking is the greatest single cause of illness and premature death in the UK. Worldwide, tobacco kills 7 million people every year. Almost a million deaths are due to non-smokers being exposed to second-hand smoke. A ... Smoking increases your risk of developing various other conditions. These include: Dementia. Optic neuropathy - this.
Weiterführende Lektüre und Referenzen
- Leber hereditary optic neuropathy; MedlinePlus, National Library of Medicine.
- Mroczek-Tonska K, Kisiel B, Piechota J, Bartnik E. Leber hereditary optic neuropathy--a disease with a known molecular basis but a mysterious mechanism of pathology. J Appl Genet. 2003;44(4):529-38.
- Newman NJ. Hereditary optic neuropathies: from the mitochondria to the optic nerve. Am J Ophthalmol. 2005 Sep;140(3):517-23. doi: 10.1016/j.ajo.2005.03.017.
- Spruijt L, Kolbach DN, de Coo RF, Plomp AS, Bauer NJ, Smeets HJ, de Die-Smulders CE. Influence of mutation type on clinical expression of Leber hereditary optic neuropathy. Am J Ophthalmol. 2006 Apr;141(4):676-82. doi: 10.1016/j.ajo.2005.11.007.
- Tonska K, Kodron A, Bartnik E. Genotype-phenotype correlations in Leber hereditary optic neuropathy. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1119-23. doi: 10.1016/j.bbabio.2010.02.032. Epub 2010 Mar 6.
- Yu-Wai-Man P, Chinnery PF. Leber Hereditary Optic Neuropathy. 2000 Oct 26 [updated 2021 Mar 11]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1174/
- Yu-Wai-Man P, Griffiths PG, Hudson G, Chinnery PF. Inherited mitochondrial optic neuropathies. J Med Genet. 2009 Mar;46(3):145-58. doi: 10.1136/jmg.2007.054270. Epub 2008 Nov 10.
- Yu-Wai-Man P, Turnbull DM, Chinnery PF. Leber hereditary optic neuropathy. J Med Genet. 2002 Mar;39(3):162-9. doi: 10.1136/jmg.39.3.162.
Artikelverlauf
Artikel auch verfügbar in Englisch, Deutsch, Spanisch, Französisch, Italienisch, Portugiesisch, Hindi, Hebräisch, Arabisch, und Schwedisch.
8 Sept 2020 | Neueste Version
1 Aug 2006 | Ursprünglich veröffentlicht
Nehmen Sie an der Diskussion teil
Teilen Sie Ihre Gedanken oder Erfahrungen mit anderen in unserem Patientengemeinschaften.
Fragen, teilen, verbinden.
Durchsuchen Sie Diskussionen, stellen Sie Fragen und teilen Sie Erfahrungen zu Hunderten von Gesundheitsthemen.
Abonnieren Sie den Patienten-Newsletter
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsberatung - geschrieben, um Ihnen zu helfen, sich informiert, selbstbewusst und in Kontrolle zu fühlen.
Durch das Abonnieren akzeptieren Sie unsere Datenschutzrichtlinie. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals.