ARF guanine nucleotide exchange factor 2
Zuletzt aktualisiert 1. Okt 2024
Erfüllt die redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen
- Language
- Diskussion
- Audio-Version
- Zu bevorzugten Quellen bei Google hinzufügen
Der ARFGEF2 gene provides instructions for making a protein that helps with the movement (trafficking) of small sac-like structures (vesicles) within the cell. The ARFGEF2 protein converts a molecule called guanine diphosphate (GDP) to another molecule called guanine triphosphate (GTP). This reaction activates an ADP-ribosylation factor, a molecule that is involved in vesicle trafficking. Vesicles transport many types of molecules from the interior of the cell to its surface, where they may attach and interact with other substances, or be secreted by the cell.
Normal function
Der ARFGEF2 gene provides instructions for making a protein that helps with the movement (trafficking) of small sac-like structures (vesicles) within the cell. The ARFGEF2 protein converts a molecule called guanine diphosphate (GDP) to another molecule called guanine triphosphate (GTP). This reaction activates an ADP-ribosylation factor, a molecule that is involved in vesicle trafficking. Vesicles transport many types of molecules from the interior of the cell to its surface, where they may attach and interact with other substances, or be secreted by the cell.
Conditions referring to this gene or chromosome
Other names
ADP-ribosylation factor guanine nucleotide-exchange factor 2
BIG2
BIG2_HUMAN
brefeldin A-inhibited guanine nucleotide-exchange protein 2
Related patient information and medicines
Patient information leaflet
Myelom
Any bone can be affected but the most common sites where pain first develops are the lower back, the pelvis and the ribs. The pain tends to be persistent and made worse by movement. Fractures. Affected bones may easily break (fracture) following a mild injury or even no injury. Compression of nerves coming out of the spinal cord. The compression.
Patient information leaflet
Kehlkopfkrebs
It is sometimes called laryngeal cancer (cancer of the larynx). However, the throat includes other nearby structures as well as the voice box (larynx). Laryngeal cancer is just one type of cancer that can occur in the throat. Throat cancers and cancers that affect the mouth, are together all called oropharyngeal cancers. How common is throat.
Patient information leaflet
Mundkrebs
Chemotherapy may also be advised if the cancer ... Other treatments Newer treatments are being used in research for the treatment of mouth cancer: Targeted therapy is a type of chemotherapy that only affects or targets cancer cells: The advantage it is hoped to have over conventional chemotherapy is that it shouldn't harm healthy cells. Epidermal.
Patient information leaflet
Rheumatoide Arthritis
Rheumatoid arthritis causes inflammation, pain, and swelling of joints. Persistent inflammation over time can damage affected joints. The severity can vary from mild to severe. Surgery is needed in some cases i... What is rheumatoid arthritis. Arthritis means inflammation of joints. Rheumatoid arthritis (RA) is a fairly common form of arthritis..
Patient information leaflet
Blutgerinnungstests
Blutgerinnungstests are used to diagnose and assess bleeding problems and to monitor people who take warfarin or other anticoagulant medicines. You may be advised to have blood clotting tests: If you have a suspected bleeding disorder. For example, if you bleed a lot after cuts, or if you bruise easily. If you have certain liver diseases that can.
Patient information leaflet
Behandlung von Typ-2-Diabetes
Although Diabetes cannot be cured, it can be treated successfully. If a high blood sugar level is brought down to a normal level, your symptoms will ease and your risk of long-term complications will be much lower. Managing type 2 diabetes Keeping your blood sugar (glucose) well controlled is key to reducing your risk of long-term complications.
Weiterführende Lektüre und Referenzen
- ARF guanine nucleotide exchange factor 2; MedlinePlus, National Library of Medicine.
- Lian G, Sheen V. Cerebral developmental disorders. Curr Opin Pediatr. 2006 Dec;18(6):614-20. doi: 10.1097/MOP.0b013e328010542d.
- Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V. Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia. J Comp Neurol. 2006 Jan 20;494(3):476-84. doi: 10.1002/cne.20806.
- Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat Genet. 2004 Jan;36(1):69-76. doi: 10.1038/ng1276. Epub 2003 Nov 30.
- Shin HW, Morinaga N, Noda M, Nakayama K. BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity. Mol Biol Cell. 2004 Dec;15(12):5283-94. doi: 10.1091/mbc.e04-05-0388. Epub 2004 Sep 22.
- Shin HW, Shinotsuka C, Nakayama K. Expression of BIG2 and analysis of its function in mammalian cells. Methods Enzymol. 2005;404:206-15. doi: 10.1016/S0076-6879(05)04020-6.
Artikelverlauf
Artikel auch verfügbar in Englisch, Deutsch, Spanisch, Französisch, Italienisch, Portugiesisch, Hindi, Hebräisch, Arabisch, und Schwedisch.
1. Okt 2024 | Neueste Version
1 Nov 2007 | Ursprünglich veröffentlicht
Nehmen Sie an der Diskussion teil
Teilen Sie Ihre Gedanken oder Erfahrungen mit anderen in unserem Patientengemeinschaften.
Fragen, teilen, verbinden.
Durchsuchen Sie Diskussionen, stellen Sie Fragen und teilen Sie Erfahrungen zu Hunderten von Gesundheitsthemen.
Abonnieren Sie den Patienten-Newsletter
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsberatung - geschrieben, um Ihnen zu helfen, sich informiert, selbstbewusst und in Kontrolle zu fühlen.
Durch das Abonnieren akzeptieren Sie unsere Datenschutzrichtlinie. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals.