cone-rod homeobox
Zuletzt aktualisiert 18. Aug 2020
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Der CRX gene provides instructions for making a protein called the cone-rod homeobox protein. This protein is found in the eyes, specifically in the light-sensitive tissue at the back of the eye called the retina. The cone-rod homeobox protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. On the basis of this action, this protein is called a transcription factor.
Normal function
Der CRX gene provides instructions for making a protein called the cone-rod homeobox protein. This protein is found in the eyes, specifically in the light-sensitive tissue at the back of the eye called the retina. The cone-rod homeobox protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. On the basis of this action, this protein is called a transcription factor.
In the retina, the cone-rod homeobox protein is necessary for the normal development of light-detecting cells called photoreceptors. Through its actions as a transcription factor, the cone-rod homeobox protein helps photoreceptor cells mature into two types: rods and cones. Rods are needed for vision in low light, while cones are needed for vision in bright light, including colour vision. The protein also helps maintain these cells and preserve vision.
Conditions referring to this gene or chromosome
Other names
cone-rod homeobox protein
CORD2
CRD
LCA7
orthodenticle homeobox 3
OTX3
Related patient information and medicines
Patient information leaflet
Zervikale Insuffizienz und Naht
Different-sized pessaries are available, and the device is removed at 37 weeks, or when labour begins, if this is sooner. One of two different techniques (the Shirodkar suture or the McDonald suture) may be offered but the principles are similar. The Shirodkar suture is placed a little higher and deeper than the McDonald. The procedure uses a band.
Patient information leaflet
Sehprobleme
Visual problems can arise from problems affecting different parts of the eye. The macula is ... This is the part of the retina that is the most densely packed with rods and cones, which are the cells that help with "seeing". Nerve signals pass from these "seeing" cells in the retina down nerve fibres in the optic nerve to the area of the brain.
Patient information leaflet
Netzhautablösung
The retina is a structure at the back of the eye which is essential for sight. When two layers of tissue in the retina become separated, it is known as a retinal tear or detachment. What is retinal ... Retinal detachment (RD) is when the tissue at the back of the eye (retina) pulls away from its regular position, causing vision loss. If the retina.
Patient information leaflet
Farbenblindheit
... How do we see colour. Different colours are seen by special cells in the retina at the back of your eye. There are two types of cells, called rods and cones. Cones are concerned with colour vision. There are three types of cones: red cones, blue cones and green cones. Each type of cone senses a different range of light. Therefore the.
Patient information leaflet
Netzhautarterienverschluss
Retinal artery occlusion occurs when the retinal artery or one of its branches becomes blocked. This cuts off the blood and nutrient supply to the nerve layer ... When you look at an object, light from the object passes through the cornea of your eye, then the lens and then the retina at the back of your eye. Nerve messages pass from the seeing.
Patient information leaflet
Skoliose und Kyphose
Skoliose ist a back condition that causes Arztpraxis (back) spine to curve to the side - either left or right. Most cases develop in children between the ages of 9 and 14 years during the growth spurt of puberty. Scoliosis is usually mild and needs no treatment. For more severe cases treatments include specific exercises, a back brace or occasionally.
Weiterführende Lektüre und Referenzen
- cone-rod homeobox; MedlinePlus, National Library of Medicine.
- Huang L, Li S, Xiao X, Jia X, Wang P, Guo X, Zhang Q. Screening for variants in 20 genes in 130 unrelated patients with cone-rod dystrophy. Mol Med Rep. 2013 Jun;7(6):1779-85. doi: 10.3892/mmr.2013.1415. Epub 2013 Apr 5.
- Huang L, Xiao X, Li S, Jia X, Wang P, Guo X, Zhang Q. CRX variants in cone-rod dystrophy and mutation overview. Biochem Biophys Res Commun. 2012 Oct 5;426(4):498-503. doi: 10.1016/j.bbrc.2012.08.110. Epub 2012 Aug 30.
- Huang L, Zhang Q, Li S, Guan L, Xiao X, Zhang J, Jia X, Sun W, Zhu Z, Gao Y, Yin Y, Wang P, Guo X, Wang J, Zhang Q. Exome sequencing of 47 chinese families with cone-rod dystrophy: mutations in 25 known causative genes. PLoS One. 2013 Jun 11;8(6):e65546. doi: 10.1371/journal.pone.0065546. Print 2013.
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18. Aug 2020 | Neueste Version
1 Feb 2016 | Ursprünglich veröffentlicht
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