KN motif and ankyrin repeat domains 2
Zuletzt aktualisiert 18. Aug 2020
Erfüllt die redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen
- Language
- Diskussion
- Audio-Version
- Zu bevorzugten Quellen bei Google hinzufügen
Der KANK2 gene provides instructions for making a protein called SRC-interacting protein (SIP). SIP regulates proteins called steroid receptor coactivators (SRCs), which play critical roles in turning on (activating) certain genes. Within cells, SIP attaches (binds) to SRCs in the fluid surrounding the nucleus (the cytoplasm). By holding SRCs in the cytoplasm, SIP prevents these proteins from entering the nucleus to activate genes. In this way, SIP helps to control gene activity.
Normal function
Der KANK2 gene provides instructions for making a protein called SRC-interacting protein (SIP). SIP regulates proteins called steroid receptor coactivators (SRCs), which play critical roles in turning on (activating) certain genes. Within cells, SIP attaches (binds) to SRCs in the fluid surrounding the nucleus (the cytoplasm). By holding SRCs in the cytoplasm, SIP prevents these proteins from entering the nucleus to activate genes. In this way, SIP helps to control gene activity.
SIP is found in many organs and tissues, including the skin and kidneys. Little is known about its specific roles in various parts of the body.
Conditions referring to this gene or chromosome
Other names
ANKRD25
ankyrin repeat domain 25
ankyrin repeat domain-containing protein 25
KIAA1518
kidney ankyrin repeat-containing protein 2
matrix-remodeling-associated protein 3
matrix-remodelling associated 3
MXRA3
PPKWH
SIP
SRC-1 interacting protein
SRC-1-interacting protein
SRC-interacting protein
SRC1-interacting protein
Related patient information and medicines
Patient information leaflet
Überprüfen Sie Ihre Medikamente auf Wechselwirkungen
Use this Medikamenten- und Wechselwirkungsprüfer zur see whether dein medicines, supplements, vitamins, foods, or certain health conditions may interact with each other. It can help you understand potential risks, avoid unwanted side effects, and decide when it’s important to speak to a pharmacist, GP, or other healthcare professional. The tool is.
Patient information leaflet
Axiale Spondyloarthritis
Axiale Spondyloarthritis (auch bekannt als axSpA oder axial SpA) is a painful, chronic Arthritis that mainly affects the joints of the spine, and also the joints connecting each side of the base of the spine with the pelvis (sacroiliac joints). It can also affect other joints in the body, as well as tendons and ligaments. It is divided into: 1).
Patient information leaflet
Mandelentfernung
A tonsillectomy is an operation to remove the tonsils from the back of the throat. Other leaflets explain more about tonsils, sore throats and throat infections. This leaflet covers risks and benefits of the operation and what to expect before, during and after a tonsillectomy. Note : the information below is a general guide only. The arrangements.
Patient information leaflet
Baker-Zyste
A Baker's cyst is a swelling that can develop behind the knee. It most commonly occurs if there is an underlying problem with the knee such as osteoarthritis. Symptoms can include pain, swelling and tightness behind the knee. Sometimes, a Baker's cyst can split open (rupture) and cause symptoms in the calf that can be similar to a deep vein.
Patient information leaflet
CT-Scan
Note : the information below is a general guide only. The arrangements, and the way tests are performed, may vary between different hospitals. Always follow the instructions given by your doctor or local hospital. What is a CT scan. It can give quite clear pictures of the inside of your body. In particular, it can give good pictures of soft.
Patient information leaflet
Kniegelenkersatz
A knee replacement is an operation to replace damaged parts of the knee joint. The new part of the joint is called a prosthesis. The outcomes are usually very good and much better than they were when the surgery was first introduced. A knee replacement is a major operation and is usually only considered when all other options have been exhausted..
Weiterführende Lektüre und Referenzen
- KN motif and ankyrin repeat domains 2; MedlinePlus, National Library of Medicine.
- Gee HY, Zhang F, Ashraf S, Kohl S, Sadowski CE, Vega-Warner V, Zhou W, Lovric S, Fang H, Nettleton M, Zhu JY, Hoefele J, Weber LT, Podracka L, Boor A, Fehrenbach H, Innis JW, Washburn J, Levy S, Lifton RP, Otto EA, Han Z, Hildebrandt F. KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. J Clin Invest. 2015 Jun;125(6):2375-84. doi: 10.1172/JCI79504. Epub 2015 May 11.
- Ramot Y, Molho-Pessach V, Meir T, Alper-Pinus R, Siam I, Tams S, Babay S, Zlotogorski A. Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair. J Med Genet. 2014 Jun;51(6):388-94. doi: 10.1136/jmedgenet-2014-102346. Epub 2014 Mar 26.
- Zhang Y, Zhang H, Liang J, Yu W, Shang Y. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. EMBO J. 2007 Jun 6;26(11):2645-57. doi: 10.1038/sj.emboj.7601710. Epub 2007 May 3.
- Zhu Y, Kakinuma N, Wang Y, Kiyama R. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. Biochim Biophys Acta. 2008 Feb;1780(2):128-33. doi: 10.1016/j.bbagen.2007.09.017. Epub 2007 Oct 4.
Artikelverlauf
Artikel auch verfügbar in Englisch, Deutsch, Spanisch, Französisch, Italienisch, Portugiesisch, Hindi, Hebräisch, Arabisch, und Schwedisch.
18. Aug 2020 | Neueste Version
1 Nov 2015 | Ursprünglich veröffentlicht
Nehmen Sie an der Diskussion teil
Teilen Sie Ihre Gedanken oder Erfahrungen mit anderen in unserem Patientengemeinschaften.
Fragen, teilen, verbinden.
Durchsuchen Sie Diskussionen, stellen Sie Fragen und teilen Sie Erfahrungen zu Hunderten von Gesundheitsthemen.
Abonnieren Sie den Patienten-Newsletter
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsberatung - geschrieben, um Ihnen zu helfen, sich informiert, selbstbewusst und in Kontrolle zu fühlen.
Durch das Abonnieren akzeptieren Sie unsere Datenschutzrichtlinie. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals.