Can I take Pregabalin and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking pregabalin and Shortec (oxycodone) together can significantly increase the risk of severe drowsiness, dizziness, and breathing difficulties. Both medications slow down the central nervous system, and when combined, their effects are much stronger than when taken alone. In serious cases, this can lead to extreme sleepiness, shallow breathing, or even coma.
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Why this happens
Both drugs are 'central nervous system depressants'. Pregabalin works by calming overactive nerves, while Shortec (an opioid) works by blocking pain signals in the brain. Because they both slow down brain activity and the signals that control breathing, they have an 'additive' effect, meaning they 'double up' on these side effects.
What you should do
You should only take these two medicines together if they have been specifically prescribed this way by your doctor. If you are taking both, start with the lowest possible doses. Avoid driving or operating machinery until you know how the combination affects you. Seek urgent medical help if you experience extreme sleepiness, confusion, or slow, shallow breathing. Avoid drinking alcohol while taking these medications.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
25 Jan 2026 | Ursprünglich veröffentlicht

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