Can I take Atorvastatin and Shiitake together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking shiitake mushrooms (especially in concentrated supplement form) alongside atorvastatin may increase the risk of muscle-related side effects, such as muscle aches, weakness, or tenderness. In rare cases, this could lead to a more serious condition called rhabdomyolysis, which can damage the kidneys.
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Why this happens
Shiitake mushrooms naturally contain a substance called eritadenine, which helps lower cholesterol. They also contain small amounts of naturally occurring statin-like compounds (similar to lovastatin). When taken with atorvastatin, these effects can add together (an additive effect), potentially increasing the level of statin activity in your body beyond what was intended by your prescription.
What you should do
If you eat shiitake mushrooms occasionally as part of a normal diet, the risk is very low. However, you should avoid taking concentrated shiitake supplements or large medicinal amounts without speaking to your doctor first. If you experience any unexplained muscle pain, tenderness, or weakness while taking these together, contact your GP immediately.
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Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
24 Jan 2026 | Ursprünglich veröffentlicht

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