coiled-coil domain 40 molecular ruler complex subunit
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The CCDC40 gene provides instructions for making a protein that is involved in the assembly of a larger group of proteins (a complex) called dynein. Dynein functions within cell structures called cilia and flagella. Cilia are microscopic, finger-like projections that stick out from the surface of cells. Coordinated back and forth movement of cilia can move the cell or the fluid surrounding the cell. Flagella are similar to cilia, but flagella are found only in sperm cells. Dynein makes up the structures (arms) that produce the force needed for cilia and flagella to move.
Normal function
The CCDC40 gene provides instructions for making a protein that is involved in the assembly of a larger group of proteins (a complex) called dynein. Dynein functions within cell structures called cilia and flagella. Cilia are microscopic, finger-like projections that stick out from the surface of cells. Coordinated back and forth movement of cilia can move the cell or the fluid surrounding the cell. Flagella are similar to cilia, but flagella are found only in sperm cells. Dynein makes up the structures (arms) that produce the force needed for cilia and flagella to move.
Dynein forms structures known as inner dynein arms (IDAs) and outer dynein arms (ODAs) within the core of cilia and flagella (the axoneme). Coordinated movement of the dynein arms causes the entire axoneme to bend back and forth. The CCDC40 protein is necessary for the proper assembly of the IDAs, which play a central role in the coordinated movement of cilia and flagella.
Researchers suspect that the CCDC40 protein is also involved in the proper assembly of the nexin-dynein regulatory complex, which helps regulate and coordinate the activity of the inner and outer dynein arms. By helping with the assembly of both the IDAs and the nexin-dynein regulatory complex, the CCDC40 protein plays a central role in the coordinated movement of cilia and flagella.
Conditions referring to this gene or chromosome
Other names
CFAP172
coiled-coil domain containing 40
coiled-coil domain containing protein 40
FAP172
FLJ20753
FLJ32021
KIAA1640
Related patient information and medicines
Patient information leaflet
Notfallverhütung
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Antiphospholipid-Syndrom
This increases the risk of developing blood clots (called thromboses) within blood vessels. APS can cause disability, serious illness and even death in a pregnant woman or her unborn baby if untreated. Unfortunately, it is a disease that is often under-recognised and under-diagnosed. This is probably because it can cause so many different.
Patient information leaflet
Ausgebliebene Perioden
If you are using certain types of ... Some types of contraception may stop periods. They do not do so in all women; however, it is normal not to have periods (or to have very light periods) if you are using: The contraceptive progestogen-only pill (POP, or mini-pill). The levonorgestrel intrauterine device - sometimes called a coil. A progestogen.
Patient information leaflet
Levonorgestrel-Intrauterinsystem
The levonorgestrel intrauterine device (LNG-IUD), previously known as the intrauterine system (IUS) is a small, flexible, plastic device which sits inside the womb (uterus). The levonorgestrel intrauterine device (LNG-IUD) is a very effective method of contraception. Some types of LNG-IUD may also be used to treat heavy periods (menorrhagia) and.
Patient information leaflet
Bakterielle Vaginose
Was ist normal vaginal acidity. Acidity is measured on the pH scale in which lower numbers are more acidic and higher numbers are more alkaline. The normal pH of the vagina is 3.8-4.5. As soon as the pH increases above 4.5, anaerobic bacteria start to overgrow and lactobacilli (which maintain the acidity) start to die off. What causes bacterial.
Weiterführende Lektüre und Referenzen
- coiled-coil domain 40 molecular ruler complex subunit; MedlinePlus, National Library of Medicine.
- Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE, Daniels ML, Noone PG, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A, Dixit A, O'Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD; Uk10k; Chung EM, Shoemark A, Knowles MR, Omran H, Mitchison HM. Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms. Hum Mutat. 2013 Mar;34(3):462-72. doi: 10.1002/humu.22261. Epub 2013 Feb 11.
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30. Sept. 2025 | Neueste Version
1 Sept 2025 | Ursprünglich veröffentlicht
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