Can I take Omeprazole and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
Erfüllt die Anforderungen des Patienten redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen Sie
- Sprache
- Diskussion
Taking omeprazole and sertraline together can increase the amount of sertraline in your bloodstream. This may increase the risk of side effects from sertraline, such as feeling sick (nausea), tremors, sleep problems, or feeling agitated. In rare cases, it could lead to a serious condition called serotonin syndrome, which causes high body temperature, sweating, and confusion.
In diesem Artikel:
Lesen Sie unten weiter
Why this happens
Sertraline is broken down in the liver by certain proteins (enzymes). Omeprazole can slow down these proteins, which means the sertraline stays in your body longer and reaches higher levels than intended.
What you should do
You can take these medicines together, but you should be aware of increased side effects. If you notice you are feeling more anxious, shaky, or unwell after starting omeprazole, speak to your doctor. They may suggest a lower dose of sertraline or a different type of indigestion medicine (like famotidine or lansoprazole) that is less likely to interfere.
Lesen Sie unten weiter
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Behandlung und Medikamente
Can I take Citalopram and Co codamol together?
Taking these two medicines together can increase the risk of a rare but serious condition called serotonin syndrome. It can also make you feel more drowsy or dizzy than usual. Additionally, citalopram may slightly reduce how well the codeine part of the co-codamol works to relieve your pain.

Behandlung und Medikamente
Can I take Idapamide and Ramipril together?
Taking indapamide and ramipril together can cause your blood pressure to drop too low, especially when you first start the combination. This can make you feel dizzy, lightheaded, or faint. It can also put extra strain on your kidneys.
Lesen Sie unten weiter
Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
25 Jan 2026 | Ursprünglich veröffentlicht

Fragen, teilen, verbinden.
Stöbern Sie in Diskussionen, stellen Sie Fragen, und tauschen Sie Erfahrungen zu Hunderten von Gesundheitsthemen aus.

Fühlen Sie sich unwohl?
Beurteilen Sie Ihre Symptome online und kostenlos
Melden Sie sich für den Patienten-Newsletter an
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsratschläge – geschrieben, damit Sie sich informiert, sicher und unter Kontrolle fühlen.
Mit Ihrer Anmeldung akzeptieren Sie unsere Datenschutzerklärung. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals weiter.