Can I take Sertraline and Tramadol together?
Drug interaction guide
Originally published 25 Jan 2026
Erfüllt die Anforderungen des Patienten redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen Sie
- Sprache
- Diskussion
Taking these two medicines together significantly increases the risk of a rare but very serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. In severe cases, it can lead to seizures or loss of consciousness.
In diesem Artikel:
Lesen Sie unten weiter
Why this happens
Both sertraline (an SSRI antidepressant) and tramadol (a strong painkiller) increase the levels of serotonin in the brain. When used together, the effect is additive, which can push serotonin levels into a dangerous range. Additionally, sertraline can slow down the way the body breaks down tramadol, leading to higher levels of the painkiller in your system.
What you should do
You should speak to your doctor before taking these two medicines together. They may prefer to prescribe an alternative painkiller that does not affect serotonin. If your doctor decides you must take both, they will monitor you closely. Seek urgent medical help immediately if you experience high fever, shivering, severe muscle stiffness, or confusion.
Lesen Sie unten weiter
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Behandlung und Medikamente
Can I take Bisoprolol and Trimbow pmdi // pressurised inhalation together?
Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Bisoprolol may cause the airways to narrow, making it harder to breathe and potentially triggering asthma or COPD symptoms. It also makes the formoterol in the Trimbow inhaler less effective at opening your airways.
Behandlung und Medikamente
Can I take Esomeprazole and Trazodone together?
Esomeprazole may reduce the amount of trazodone that your body absorbs. This could potentially make trazodone less effective at treating your symptoms (such as depression or sleep issues). Additionally, both medications can rarely affect the electrical activity of your heart, though this risk is generally low.
Lesen Sie unten weiter
Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
25 Jan 2026 | Ursprünglich veröffentlicht
Fragen, teilen, verbinden.
Stöbern Sie in Diskussionen, stellen Sie Fragen, und tauschen Sie Erfahrungen zu Hunderten von Gesundheitsthemen aus.
Fühlen Sie sich unwohl?
Beurteilen Sie Ihre Symptome online und kostenlos
Melden Sie sich für den Patienten-Newsletter an
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsratschläge – geschrieben, damit Sie sich informiert, sicher und unter Kontrolle fühlen.
Mit Ihrer Anmeldung akzeptieren Sie unsere Datenschutzerklärung. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals weiter.