Perindopril - ein ACE-Hemmer

About perindopril

Perindopril belongs to a class of medicines called angiotensin-converting enzyme inhibitors, or ACE inhibitors. It is prescribed for a number of different reasons. You may have been prescribed it to reduce hoher Blutdruck (Hypertonie), or to treat Herzinsuffizienz, or to protect your heart and blood vessels from damage following a heart attack or following certain procedures. Your doctor will tell you why it has been prescribed for you.

ACE inhibitors like perindopril prevent your body from creating a hormone known as angiotensin II. They do this by blocking (inhibiting) a chemical called angiotensin-converting enzyme. This widens your blood vessels and helps to reduce the amount of water put back into your blood by your kidneys.

These actions help to decrease blood pressure in people who have blood pressure which is higher than normal. Although people with high blood pressure often do not feel unwell, if left untreated, high blood pressure can harm the heart and damage blood vessels, leading to a heart attack or stroke.

Heart failure is a condition where your heart does not work as well as it should. Because of this, there may be too much circulating fluid in your blood vessels. Perindopril helps to reduce this. It also appears to have a protective effect on the heart.

You may be prescribed perindopril on its own, or alongside other medicines to help your condition. The brand of perindopril called Coversyl® Arginine Plus contains a medicine called indapamide. This brand is prescribed for people with high blood pressure. Combination brands like this help to reduce the total number of tablets you need to take each day.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking perindopril it is important that your doctor knows:

• Wenn Sie schwanger sind, versuchen, schwanger zu werden oder stillen.

• Wenn Sie Probleme mit der Funktion Ihrer Nieren haben oder Probleme mit der Funktion Ihrer Leber.

• Wenn Ihrem Körper Flüssigkeit fehlt (Dehydration) – zum Beispiel, wenn Sie kürzlich Durchfall oder Übelkeit hatten.

• Wenn Ihnen gesagt wurde, dass sich Fettablagerungen an den Wänden Ihrer Arterien angesammelt haben, eine Erkrankung namens Arteriosklerose.

• Wenn Sie eine bestimmte Art von schlechter Durchblutung haben, die periphere arterielle Verschlusskrankheit genannt wird.

• If you have collagen vascular disease - this includes conditions such as systemic lupus erythematosus (SLE) and scleroderma.

• Wenn Ihnen gesagt wurde, dass Sie eine Herzmuskelerkrankung (Kardiomyopathie) oder eine Verengung des Hauptblutgefäßes von Ihrem Herzen (Aortenstenose) haben.

• Falls Sie jemals eine Reaktion hatten, bei der Ihr Gesicht, Ihre Zunge oder Ihr Hals anschwellen (Angioödem).

• Wenn Sie eine Desensibilisierungstherapie gegen Bienen- und Wespenstiche erhalten.

• Wenn Sie eine Dialysebehandlung oder eine Behandlung zur Entfernung von Cholesterin aus Ihrem Blut durch eine Maschine (LDL-Apherese) erhalten.

• Wenn Sie andere Medikamente einnehmen. Dazu gehören alle Medikamente, die Sie einnehmen und die ohne Rezept erhältlich sind, sowie pflanzliche und ergänzende Medikamente.

• Wenn Sie jemals eine allergische oder ungewöhnliche Reaktion auf einen anderen ACE-Hemmer (wie Lisinopril, Ramipril oder Enalapril) oder auf ein anderes Medikament gehabt haben.

• Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about perindopril and will provide you with a full list of side-effects which you may experience from taking it.

• Take perindopril exactly as your doctor tells you to. You will be asked to take one dose each day.

• Your doctor will advise you to take your very first dose at bedtime. This is because the first dose can make you feel dizzy.

• After the first dose, take perindopril in the morning. Swallow the tablet with a drink of water. The ideal time to take your dose is 30-60 minutes before breakfast. This is because more of the dose is absorbed if you take the tablet when your stomach is empty.

• If you forget to take a dose at your usual time, take it as soon as you remember. If you do not remember until the following day, skip the forgotten dose. Do not take two doses at the same time to make up for a missed dose.

• Versuchen Sie, Ihre regelmäßigen Termine bei Ihrem Arzt einzuhalten. So kann Ihr Fortschritt überwacht werden. Ihr Arzt möchte möglicherweise gelegentlich Blutuntersuchungen durchführen, um sicherzustellen, dass Ihre Nieren gut funktionieren.

• Each time you collect a prescription, check to make sure the tablets look the same as you have had before. This is because there are two types of perindopril tablet and several strengths of each type of tablet. If you are unsure about the tablets, or if you have any questions about your prescription, please ask your pharmacist for advice.

• Es ist sehr wichtig, dass Sie die Ernährungs- und Lebensstilempfehlungen befolgen, die Ihnen Ihr Arzt gibt. Dazu können Ratschläge zu einer gesunden Ernährung, Nichtrauchen und regelmäßiger Bewegung gehören.

• If you buy any medicines, check with a pharmacist that they are suitable to take with perindopril. This is because some medicines (such as anti-inflammatory painkillers and indigestion remedies) may interfere with your treatment.

• It is likely that your doctor will advise that you do not use salt substitutes while you are taking perindopril. These products have a high content of potassium which could be harmful for you.

• If you drink alcohol, ask your doctor for advice about drinking alcohol while you are on perindopril. Alcoholic drinks may make you feel light-headed or dizzy, and may not be advisable for you.

• If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking perindopril tablets. This is because some anaesthetics may cause your blood pressure to drop too low.

• Treatment with perindopril is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with perindopril. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Wenn Sie andere Symptome bemerken, die Ihrer Meinung nach auf die Tabletten zurückzuführen sein könnten, sprechen Sie mit Ihrem Arzt oder Apotheker für weitere Ratschläge.

• Bewahren Sie alle Medikamente außerhalb der Reichweite und Sicht von Kindern auf.

• An einem kühlen, trockenen Ort aufbewahren, fern von direkter Hitze und Licht.