Isosorbidmononitrat
Tardisc, Xismox
Begutachtet von Sid DajaniZuletzt aktualisiert von Michael Stewart, MRPharmSLast updated 20. Okt 2024
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Isosorbide mononitrate helps to prevent angina chest pain from developing.
It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as Glyceroltrinitrat (GTN), for if you get angina pain.
The most common side-effect is headache. This should pass after a few days.
At a glance
Isosorbide mononitrate is a medicine used to prevent angina chest pain and treat heart failure.
It works by relaxing and widening blood vessels to improve blood flow to the heart and reduce strain.
Doses are taken once, two, or three times daily depending on the type and doctor's instructions.
Do not chew or crush modified-release tablets or capsules.
This medicine is not for treating an angina attack; use your prescribed short-acting nitrate for that.
Common side-effects include headache, dizziness, tiredness, fast heartbeat, and flushing.
Avoid alcohol while taking this medicine as it can increase side-effects.
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About isosorbide mononitrate
Art des Medikaments | A nitrate |
Verwendet für | Angina prevention; heart failure |
Auch genannt | Carmil® XL, Chemydur® XL, Elantan® LA, Imdur®, Isib® XL, Ismo®, Isodur® XL, Isotard® XL, Medomon® XL, Modisal® XL, Monomax® SR, Monomil® XL, Monosorb® XL, Nyzamac® SR, Relosorb® XL, Tardisc® XL, Trangina® XL, Xismox® XL, Zemon® XL, |
Verfügbar als | Tablets, modified-release (longer-acting) tablets, and modified-release (longer-acting) capsules |
Isosorbide mononitrate helps to prevent Angina chest pain from developing. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. The narrowing makes it more difficult for blood to flow to your heart muscle.
Isosorbide mononitrate works in two ways. It relaxes blood vessels in your body (causing them to widen) and this reduces the strain on your heart, making it easier for your heart to pump blood around your body. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle.
Isosorbide mononitrate is also sometimes prescribed alongside other medicines for people with Herzinsuffizienz. This is a condition where the heart does not beat as efficiently as it should.
Before taking isosorbide mononitrate
Zurück zum InhaltSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows:
Wenn Sie schwanger sind oder stillen.
Wenn Sie Probleme mit der Funktionsweise Ihrer Leber haben oder Probleme mit der Funktionsweise Ihrer Nieren.
Wenn Sie niedrigen Blutdruck haben.
If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia).
Wenn Sie eine unteraktive Schilddrüse haben.
Wenn Sie eine Augenerkrankung namens Glaukom haben.
If you have recently had a head injury or a heart attack.
Wenn Sie jemals eine allergische Reaktion auf ein Medikament hatten.
If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction.
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How to take isosorbide mononitrate
Zurück zum InhaltBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about nitrate medicines, and it will also provide you with a full list of side-effects which you could experience from taking isosorbide mononitrate.
Some brands of isosorbide mononitrate tablets should be taken two or three times a day. Longer-acting tablets and capsules are taken once daily in the morning. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. You can take your doses either before or after meals.
Swallow the tablet/capsule whole - do not chew or crush it before you swallow. This is because the tablets/capsules are specially made to release the medicine they contain in a controlled way.
If you forget to take a dose, take it as soon as you remember. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.
Das Beste aus Ihrer Behandlung herausholen
Zurück zum InhaltIsosorbide mononitrate tablets and capsules are not suitable to take to treat the pain of an angina attack. Your doctor will prescribe you a short-acting nitrate for you to take if this happens. Glyceryl trinitrate (GTN) is commonly prescribed for this.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress
The longer you take isosorbide mononitrate, the more your body can become used to it (called tolerance), and then it can have less of an effect. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. It is important that you follow the instructions your doctor gives to you about when to take your doses.
It is best not to drink alcohol while you are on isosorbide mononitrate. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed.
If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking.
If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate.
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Can isosorbide mononitrate cause problems?
Zurück zum InhaltAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with isosorbide mononitrate. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common isosorbide mononitrate side-effects | Was kann ich tun, wenn ich das erlebe? |
Kopfschmerzen | Ask your doctor or pharmacist to recommend a suitable painkiller. This side-effect usually disappears after a few days |
Sich schwindelig oder müde fühlen | Fahren Sie nicht und benutzen Sie keine Werkzeuge oder Maschinen, während Sie beeinträchtigt sind |
Fast heartbeat; flushing | Wenn eines dieser Probleme auftritt, sprechen Sie mit Ihrem Arzt |
Wenn Sie andere Symptome bemerken, die Ihrer Meinung nach auf das Medikament zurückzuführen sein könnten, sprechen Sie bitte mit Ihrem Arzt oder Apotheker für weitere Ratschläge.
How to store isosorbide mononitrate
Zurück zum InhaltBewahren Sie alle Medikamente außerhalb der Reichweite und Sicht von Kindern auf.
An einem kühlen, trockenen Ort aufbewahren, fern von direkter Hitze und Licht.
Wichtige Informationen über alle Medikamente
Zurück zum InhaltWichtige Informationen über alle Medikamente
Nehmen Sie niemals mehr als die vorgeschriebene Dosis ein. Wenn Sie vermuten, dass Sie oder jemand anderes eine Überdosis dieses Medikaments eingenommen haben könnte, gehen Sie in die Notaufnahme Ihres örtlichen Krankenhauses. Nehmen Sie den Behälter mit, auch wenn er leer ist.
Dieses Medikament ist für Sie. Geben Sie es niemals an andere Personen weiter, auch wenn deren Zustand ähnlich erscheint wie Ihrer.
Bewahren Sie keine abgelaufenen oder unerwünschten Medikamente auf. Bringen Sie sie zu Ihrer örtlichen Apotheke, die sie für Sie entsorgt.
Wenn Sie Fragen zu diesem Medikament haben, fragen Sie Ihren Apotheker.
Berichten Sie Nebenwirkungen eines Medikaments oder Impfstoffs
Wenn Sie Nebenwirkungen bemerken, können Sie diese online über die Yellow Card website.

Unsicher beim Mischen von Medikamenten?
Überprüfen Sie mögliche Wechselwirkungen zwischen Medikamenten, Nahrungsergänzungsmitteln und Lebensmitteln, bevor Sie sie zusammen einnehmen.
Häufig gestellte Fragen
What is angina and how does isosorbide mononitrate help?
Angina is chest pain that occurs when your heart muscle doesn't get enough blood and oxygen. This is often due to narrowed coronary arteries caused by a fatty substance called atheroma. Isosorbide mononitrate helps by relaxing and widening blood vessels in your body, which reduces the strain on your heart, and also directly widens the coronary arteries to improve blood flow to the heart muscle.
Can I take isosorbide mononitrate if I have heart failure?
Yes, isosorbide mononitrate is sometimes prescribed alongside other medicines for people with heart failure. Heart failure is a condition where the heart does not pump blood as efficiently as it should.
Can I crush or chew my isosorbide mononitrate tablets or capsules?
No, you should swallow the tablet or capsule whole. Do not chew or crush it. This is because these forms of the medicine are specially designed to release the medication in a controlled way over time.
Can I drink alcohol while taking isosorbide mononitrate?
It is best not to drink alcohol while you are taking isosorbide mononitrate. Alcohol can increase your risk of experiencing side-effects such as feeling dizzy and light-headed.
What should I do if I forget to take a dose of isosorbide mononitrate?
If you forget to take a dose, take it as soon as you remember. However, if your next dose is nearly due, then you should skip the forgotten dose and take your next dose at the usual time. Do not take two doses together to make up for a missed dose.
Will my body get used to isosorbide mononitrate over time?
Yes, your body can become used to isosorbide mononitrate over time, which is called tolerance, and this can make the medicine less effective. To help prevent this, if you are prescribed more than one dose a day, your doctor may instruct you to take your doses at specific intervals to ensure a period without the medicine each day. It is important to follow your doctor's instructions about when to take your doses.
Are there any medicines I should definitely avoid taking with isosorbide mononitrate?
It is particularly important to tell your doctor if you are using any medicines to help treat erectile dysfunction. You should also check with a pharmacist about any other medicines you buy, including herbal or complementary ones, to ensure they are suitable to take with isosorbide mononitrate.
Weiterführende Literatur und Referenzen
- Manufacturer's PIL, Imdur 60 mg tablets; TopRidge Pharma Ltd, The electronic Medicines Compendium. Dated August 2017.
- Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets; Dexcel Pharma Ltd, The electronic Medicines Compendium. Dated December 2017.
- Medikamente Komplett BNF 89. Ausgabe; Britische Ärztevereinigung und Königliche Pharmazeutische Gesellschaft von Großbritannien, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Manager für die Überprüfung von Beipackzetteln – Auftragnehmer, Apotheker
BPharm (Hons), MRPharmS
Michael ist ein Gemeindapotheker, der in den Midlands und South Yorkshire praktiziert und über mehr als 20 Jahre Erfahrung in der Beratung zu Medikamenten und medizinischen Bedingungen verfügt. Er hat einen starken Hintergrund in der Gesundheitsausbildung, da er Schulungskurse für Apothekenteams und Mitarbeiter von Pflegeeinrichtungen, einschließlich Krankenschwestern, erstellt und durchgeführt hat. Er hat auch zu Apothekenbeiräten für das Management von geringfügigen Erkrankungen in der Gemeinschaft beigetragen.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
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