Etanercept

About etanercept

Etanercept is a biological medicine used to ease the symptoms of rheumatoide Arthritis and some other forms of arthritis such as Psoriasis-Arthritis, juvenile idiopathic arthritis und ankylosierende Spondylitis. It is also used to treat plaque psoriasis, which is a chronic inflammatory skin disease. A biological medicine is a medicine which is made by living organisms. The medicines mimic substances produced by your body. Biological medicines like etanercept are sometimes called cytokine modulators, or monoclonal antibodies.

Arthritis simply means inflammation of joints. Biological medicines work in arthritis by blocking chemicals in your body that are involved in inflammation. Etanercept blocks a protein called tumour necrosis factor alpha (TNF-alpha). This protein plays an important role in causing inflammation. By blocking it, etanercept reduces damage to your joints.

Etanercept is usually prescribed when other treatments have not worked sufficiently, or if other treatments are not suitable for you. If you are being treated for rheumatoid arthritis, it may be used alongside another medicine such as methotrexate. Etanercept will be prescribed for you by a specialist doctor in a hospital. It cannot be taken as a tablet, as it does not work when swallowed. Instead, it is given by an injection under your skin. You can either learn to inject yourself, or a nurse in the hospital will do it for you.

Before having etanercept

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or your child if appropriate) start having etanercept, it is important that your doctor or nurse knows:

• Wenn Sie schwanger sind oder stillen.

• If you have an infection, or if you think that you may be at risk of an infection. It is particularly important that you tell your doctor if you have ever had tuberculosis (TB).

• Wenn Sie eine Herzkrankheit haben.

• Wenn Sie Diabetes (Diabetes mellitus) haben.

• If you have ever had a blood disorder or cancer.

• If you have multiple sclerosis, an eye condition called optic neuritis, or a spinal condition called transverse myelitis.

• If you have had any liver infection or been told you have inflammation of your liver due to drinking alcohol.

• Wenn Sie andere Medikamente einnehmen. Dazu gehören alle Medikamente, die Sie ohne Rezept kaufen können, sowie pflanzliche und ergänzende Arzneimittel.

• Wenn Sie jemals eine allergische Reaktion auf ein Medikament hatten.
  

How etanercept is given

• Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about etanercept and a full list of side-effects which you may experience from having it.

• Etanercept is given as an injection under your skin. It is usually given once or twice a week. You may be given the injections by a nurse in your hospital clinic, or you may be taught how to give the injections to yourself. Your doctor or nurse will discuss these options with you.

• If you are given the injections to store at home, keep them in a fridge. You can take your dose out of the fridge about 15-30 minutes before your injection is due, to allow it to reach room temperature before it is given.

• If you are giving your own injections, always check that the solution is clear, not cloudy, and that it does not contain any bits or large particles before you administer it. So that you know exactly how the solution should look, read the description given in the manufacturer's leaflet that comes with your medicine.

• You should try to remember to use etanercept on the same day(s) each week. Make a note in your diary of which days your dose is due so that you do not forget.

• If you do forget a dose, have the injection as soon as you remember and then continue on your usual days. Always refer to the manufacturer's instructions provided with your medicine. As a guide, if you do not remember until your next dose is nearly due (for example, if it is due the following day), you should skip the missed dose but remember your next dose when it is due. Do not have two doses on the same day to make up for a missed dose.

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• You will be given a Patient Alert Card when you start this treatment. This contains some important safety information for you to read and keep. Carry the card with you, and if ever you need any medical treatment, it is important you show it to anyone who is treating you.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have some tests and X-rays from time to time to make sure the treatment is working for you.

• While you are on etanercept, tell your doctor if you come into contact with anyone who has chickenpox or shingles. This is because you may need to have treatment to protect you from these infections.

• If you need to have any vaccinations, speak with your clinic first, as some vaccines are not suitable for you while you are being treated with etanercept.

• If you have diabetes you may need to check your blood glucose levels more regularly, as this preparation can affect the levels of sugar in your blood. Your doctor will advise you about this.

• Initially, etanercept is usually prescribed for about 3-6 months. If the treatment helps you, your doctor may then decide to continue it for longer. The decision to continue or stop your treatment will depend upon your symptoms and what you and your specialist feel is best for you.

• If you need to buy any medicines, check with a pharmacist that they are suitable for you to take alongside etanercept.

Can etanercept cause problems?

Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. The table below lists some of the most common ones associated with etanercept. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve after the first few weeks of having the injections, but speak with your doctor if any of the following side-effects continue or become troublesome.

Wichtig: your doctor will discuss with you the possibility of rare but serious side-effects, such as a blood disorder. Contact your doctor straightaway if you develop a high temperature, sore throat, or any unexplained bruising or bleeding.

Wenn Sie andere Symptome bemerken, die Ihrer Meinung nach auf dieses Medikament zurückzuführen sind, sprechen Sie mit Ihrem Arzt oder Apotheker.

How to store etanercept

• Bewahren Sie alle Medikamente außerhalb der Reichweite und Sicht von Kindern auf.

• Store in a refrigerator. Do not freeze.
  

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