Asenapin Tabletten
Sycrest
Begutachtet von Sid DajaniZuletzt aktualisiert von Michael Stewart, MRPharmSLast updated 17. Apr 2023
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The usual dose is one tablet (5 mg or 10 mg), taken in the morning and evening. Place the tablet under your tongue and allow it dissolve there. Do not eat or drink for 10 minutes afterwards.
The most common side-effects are drowsiness and anxiety.
Keep your regular appointment with your doctor so your progress can be checked.
At a glance
Asenapine is an antipsychotic medicine for adults with mania caused by bipolar disorder.
It works by adjusting brain chemicals to decrease the intensity and frequency of manic episodes.
Take asenapine sublingual tablets twice daily by dissolving them under your tongue.
Do not eat or drink for 10 minutes after taking the tablet.
Common side effects include dizziness, tiredness, increased appetite, and changes in taste.
See your doctor immediately if you have muscle stiffness, high temperature, confusion or fast heartbeat.
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About asenapine tablets
Art des Medikaments | Ein antipsychotisches Medikament |
Verwendet für | Episodes of mania associated with bipolar disorder in adults |
Auch genannt | Sycrest® |
Verfügbar als | Sublingual (dissolve under the tongue) tablets |
Bipolare Störung is a long-term condition where you have periods of lows (depression) and periods of highs (mania or hypomania).
Asenapine will have been given to you to treat episodes of mania caused by bipolar disorder. It is not known exactly how it works, but it is thought to adjust the levels of certain chemicals in your brain which affect your mood. This decreases the intensity and frequency of the manic episodes you experience.
Before taking asenapine tablets
Zurück zum InhaltSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking asenapine, it is important that your doctor knows:
Wenn Sie schwanger sind oder stillen.
Wenn Sie eine Herzkrankheit oder Gefäßerkrankung haben.
Wenn Sie Leber-, Nieren- oder Prostataprobleme haben.
Wenn Sie Atemprobleme haben.
If you have any of the following: epilepsy, Demenz, Parkinson-Krankheit, Depressionen, raised pressure in your eye (glaucoma), or a condition causing muscle weakness, known as myasthenia gravis.
If you have a blood disorder.
If you have ever had yellowing of your skin and the whites of your eyes (Gelbsucht).
If you have a condition called phaeochromocytoma, a tumour on your adrenal gland.
If you have ever had an allergic reaction to any medicine.
Wenn Sie andere Medikamente einnehmen oder verwenden. Dazu gehören alle Medikamente, die Sie einnehmen und die ohne Rezept erhältlich sind, sowie pflanzliche und ergänzende Medikamente.
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How to take asenapine tablets
Zurück zum InhaltBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about asenapine tablets and a full list of side-effects which you may experience from taking them.
Take asenapine tablets exactly as your doctor tells you to. The usual dose is one tablet twice daily, with the doses taken in the morning and the evening. There are two strengths of tablet - 5 mg and 10 mg. You may be started on one strength of the tablet and then switched to the other - this will depend upon how your symptoms respond to the medicine.
Peel back the coloured tab covering the blister packaging and remove the tablet (make sure your hands are dry as you do this). Place the tablet under your tongue and allow it to dissolve there - this will only take a few seconds. In order to make sure all the medicine has been absorbed, do not eat or drink anything for 10 minutes afterwards.
If you are also taking other medicines at the same times of day as asenapine, take your other medicines first. Asenapine tablets should be taken last.
If you forget to take a dose, take it as soon as you remember, unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Das Beste aus Ihrer Behandlung herausholen
Zurück zum InhaltYour treatment will require careful monitoring to make sure that you get the best possible benefit from asenapine. Keep your regular doctor's appointments so that your progress can be checked. You may need to have some tests from time to time.
Treatment with asenapine is usually long-term unless you experience an adverse effect. Keep taking the tablets until your doctor tells you otherwise. Stopping suddenly can cause problems and your doctor will want you to reduce your dose very gradually if this becomes necessary.
Asenapine may cause your skin to become more sensitive to sunlight than normal. Use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15, especially in strong sunlight or until you know how your skin reacts. Do not use sunbeds.
If you drink alcohol, ask your doctor for advice about drinking while you are on asenapine. Alcohol will increase the chance that you experience side-effects and may not be recommended for you.
If you have diabetes you may need to check your blood sugar (glucose) more frequently, as asenapine may affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
If you are having any dental treatment or an operation, tell the person carrying out the treatment which medicines you are taking. This is important because asenapine may interfere with any anaesthetic you receive.
If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are safe to take with asenapine.
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Can asenapine cause problems?
Zurück zum InhaltAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with asenapine tablets. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common asenapine side-effects | Was kann ich tun, wenn ich das erlebe? |
Feeling dizzy, or light-headed, feeling sick (nausea) | This should pass as your body adjusts; in the meantime, try getting up more slowly and sticking to simple foods |
Feeling tired, or sleepy | Do not drive and do not use tools or machines if this happens. Do not drink alcohol |
Anxiety, increased appetite and weight, unusual movements, shaking, feeling weak, changes in the way things taste or feel in your mouth, producing too much saliva | Besprechen Sie diese mit Ihrem Arzt, wenn sie unangenehm werden |
Wichtig: if you experience any muscle stiffness, with a high temperature, confusion, a fast heartbeat and sweating, contact your doctor immediately. These may be signs of a rare but serious condition known as neuroleptic malignant syndrome.
Wichtig: if you develop any abnormal face or body movements, or feel very restless, speak with your doctor about this as soon as possible.
Wenn Sie andere Symptome bemerken, die Ihrer Meinung nach auf dieses Medikament zurückzuführen sind, sprechen Sie mit Ihrem Arzt oder Apotheker.
How to store asenapine
Zurück zum InhaltBewahren Sie alle Medikamente außerhalb der Reichweite und Sicht von Kindern auf.
An einem kühlen, trockenen Ort aufbewahren, fern von direkter Hitze und Licht.
Wichtige Informationen über alle Medikamente
Zurück zum InhaltWichtige Informationen über alle Medikamente
Nehmen Sie niemals mehr als die vorgeschriebene Dosis ein. Wenn Sie vermuten, dass Sie oder jemand anderes eine Überdosis dieses Medikaments eingenommen haben könnte, gehen Sie in die Notaufnahme Ihres örtlichen Krankenhauses. Nehmen Sie den Behälter mit, auch wenn er leer ist.
Dieses Medikament ist für Sie. Geben Sie es niemals an andere Personen weiter, auch wenn deren Zustand ähnlich erscheint wie Ihrer.
Bewahren Sie keine abgelaufenen oder unerwünschten Medikamente auf. Bringen Sie sie zu Ihrer örtlichen Apotheke, die sie für Sie entsorgt.
Wenn Sie Fragen zu diesem Medikament haben, fragen Sie Ihren Apotheker.
Berichten Sie Nebenwirkungen eines Medikaments oder Impfstoffs
Wenn Sie Nebenwirkungen bemerken, können Sie diese online über die Yellow Card website.

Unsicher beim Mischen von Medikamenten?
Überprüfen Sie mögliche Wechselwirkungen zwischen Medikamenten, Nahrungsergänzungsmitteln und Lebensmitteln, bevor Sie sie zusammen einnehmen.
Häufig gestellte Fragen
What is bipolar disorder and how does asenapine help?
Bipolar disorder is a long-term condition characterised by periods of depression (lows) and periods of mania or hypomania (highs). Asenapine is prescribed to treat the manic episodes. It is believed to work by adjusting levels of certain brain chemicals that influence mood, which helps to reduce the intensity and frequency of these manic episodes.
Are there any specific medical conditions that would prevent me from taking asenapine?
Yes, it's important to tell your doctor if you have certain conditions, as asenapine might not be suitable or may require extra care. These include heart conditions, blood vessel disease, liver, kidney, or prostate problems, breathing issues, epilepsy, dementia, Parkinson's disease, depression, glaucoma, myasthenia gravis, a blood disorder, a history of jaundice, or a phaeochromocytoma (a tumour on your adrenal gland). Your doctor needs to know your full medical history to ensure asenapine is safe for you.
Since asenapine is a sublingual tablet, how exactly should I take it?
Asenapine tablets are designed to dissolve under your tongue. You should peel back the coloured tab on the blister packaging and, with dry hands, remove the tablet. Place it under your tongue and let it dissolve; this usually takes only a few seconds. Crucially, do not eat or drink anything for 10 minutes after taking the tablet to ensure it's fully absorbed.
What should I do if I'm taking other medications in addition to asenapine?
If you are taking other medicines that are due at the same time as asenapine, you should take your other medicines first. Asenapine tablets should always be taken last. Remember to also inform your doctor about all other medicines you are taking, including over-the-counter, herbal, and complementary medicines.
Is asenapine a long-term medication, and what happens if I want to stop taking it?
Treatment with asenapine is typically long-term. You should continue taking the tablets as prescribed by your doctor and not stop unless your doctor tells you to. Stopping asenapine suddenly can cause problems, so if your doctor decides it's appropriate to discontinue the medication, they will advise you on how to reduce your dose very gradually.
Can asenapine affect my skin's sensitivity to the sun?
Yes, asenapine can make your skin more sensitive to sunlight than usual. When you are exposed to strong sunlight, or until you understand how your skin reacts, you should use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15. It's also advised not to use sunbeds.
Weiterführende Literatur und Referenzen
- Manufacturer's PIL, Sycrest® 5 mg and 10 mg Sublingual Tablets; Organon Pharma (UK) Ltd, The electronic Medicines Compendium. Dated March 2021.
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About the authorView full bio

Helen Allen, MPharm
Pharmacist, Medical Author
MPharm
Helen Allen qualified as a Pharmacist in 1979 and spent 3 years as the drug information leaflets' author for EMIS.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Artikelverlauf
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und begutachtet.
Nächste Überprüfung fällig: 15. Okt. 2027
17. Apr 2023 | Neueste Version
15 Jan 2014 | Ursprünglich veröffentlicht
Verfasst von:
Helen Allen, MPharm

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