Campylobacteriosis

What is campylobacteriosis?

Campylobacteriosis is an infectious disease caused by bacteria of the genus Campylobacter and is the most common reported bacterial cause of infectious intestinal disease in England and Wales¹ .

Pathogenesis^{2 3}

17 species and 6 subspecies exist, many of which are considered pathogenic to humans, causing enteric and extra-intestinal illnesses. Two species are responsible for most cases of enteric campylobacteriosis: Campylobacter jejuni and Campylobacter coli. They both produce a similar illness.

Campylobacteriosis is a zoonosis - that is, a disease transmitted to humans from animals or animal products.The usual route of campylobacteriosis transmission is foodborne, through eating undercooked meat and meat products. Other sources of Campylobacter spp. include raw or contaminated milk and contaminated water or ice. Some cases of campylobacteriosis occur following contact with contaminated water during recreational activities. There may be person-to-person transmission (faeco-oral route) with poor personal hygiene. Campylobacter enteritis outbreaks occasionally occur in nurseries and institutions.

97% of sporadic campylobacteriosis can be attributed to animals farmed for meat and poultry⁴ . During 2007-2009 a UK-wide, three-year stratified randomised survey of UK chicken broiler flocks was conducted to estimate the prevalence of campylobacter-infected batches of birds at slaughter. Of thirty-seven abattoirs, 79·2% were found to be colonised with Campylobacter spp., the majority of isolates being C. jejuni. Previous partial depopulation of the flock, slaughter in the summer months or autumn months, increasing bird age and higher recent mortality level in the flock were all identified as significant risk factors for Campylobacter spp. colonisation of the birds at slaughter. Time in transit to the slaughterhouse of more than 2·5 hours was identified as a protective factor⁵ .

The incubation period of campylobacteriosis can be between 1 and 11 days but is usually 2-5 days. There is limited information on the period of infectiousness but patients are probably not infectious if treated and diarrhoea has resolved.

Campylobacteriosis epidemiology³

Campylobacter spp. is the most commonly reported bacterial gastrointestinal (GI) pathogen. Campylobacter spp. reporting showed a marginal overall increasing trend from 2015 to 2019, with a peak in reporting of 102.3 cases per 100,000 population in 2018⁶ .

Campylobacteriosis has increased particularly in the older population and incidence has reduced in infants and children. A number of factors could contribute to these increased numbers - eg, an ageing population, increased travel, more eating out, changes in health-seeking behaviour⁷ . One study suggests that the rise is in fact an artefact caused by more stool samples being taken from older people⁸ .

Risikofaktoren

• Undercooked meat, especially poultry.

• Pets with diarrhoea.

• Raw and inadequately pasteurised milk.

• Contaminated water supplies.

• Occupational exposure when processing poultry in abattoirs.

• Traveller's diarrhoea, particularly in Southeast Asia.

Campylobacteriosis symptoms

Geschichte

• The incubation period of campylobacteriosis can be from 1 to 11 days but is usually 2 to 5 days.

• There is a prodromal illness of fever, headache and myalgia lasting up to 24 hours. The fever may be as high as 40°C and, whether high or low, may persist for a week.

• There are abdominal pains and cramps and profuse diarrhoea with up to 10 stools a day. The stool is watery and often bloody.

• There may be localised tenderness.

• There may be tenesmus.

• In some cases, campylobacteriosis symptoms are mild.

Prüfung

• The person often looks ill.

• Temperature may be high or low but pyrexia is present in the majority.

• The abdomen is diffusely tender; however, tenderness may be more localised as right iliac fossa pain or left iliac fossa pain.

Die Beurteilung der Dehydratation wird in den separaten Artikeln Gastroenteritis bei Erwachsenen und älteren Kindern und Gastroenteritis bei Kindern behandelt.

Nachforschungen

A sample of faeces sent for culture will usually isolate Campylobacter spp.. A stool culture is not always necessary. It is advisable to send a stool culture for a person with diarrhoea if ⁹ :

• When the clinician requires a microbiological diagnosis:

  • When there is persistent diarrhoea/malabsorption.

  • When there is blood, mucus or pus in the stool.

  • When there is a history of diarrhoea and/or vomiting, and the patient is systemically unwell.

  • When there is a history of recent hospitalisation or for inpatients as soon as infective diarrhoea is suspected.

  • When there is a history of antibiotic therapy.

• When a public health situation requires sampling to be carried out. For example:

• When investigating outbreaks of diarrhoea and/or vomiting in contacts of patients infected with organisms such as STEC (including O157) or S. Typhi:

  • When there is a suspected public health hazard (for example, if a patient with diarrhoea is a food handler).

  • Where a patient requires microbiological clearance for their occupation following past infection or contact with a case of gastrointestinal infection.

  • When an outbreak is suspected (eg, petting farm, swimming pool).

• When the patient is immunocompromised.

• When the patient has travelled within 14 days of symptoms onset.

When sending a stool sample include the following information⁹ :

• Specimen date and time of collection.

• Acute/outbreak case.

• Immune status.

• Healthcare or community acquired. If patient is hospitalised, date of admission and date of symptom onset should be included.

• Recent overseas travel including location and dates.

• Recreational/untreated water exposure.

• Farm animal exposure/animal contact.

• Food intake, for example shellfish and chicken.

• Recent antibiotic use.

• Other relevant information such as suspected food poisoning, contact with cases, food handler and occupation.

Where food poisoning with Campylobacter spp. is confirmed, the local health protection team should be notified¹⁰ .

In more severe illness, U&E and creatinine may show evidence of dehydration.

Differentialdiagnose

• Andere Infektionen - zum Beispiel:
  

  • Escherichia coli O157

  • Salmonella spp.

  • Shigella spp.

  • Amoebic dysentery

  • Listeria monocytogenes

• Blinddarmentzündung.

• Entzündliche Darmerkrankungen.

• Pseudomembranous enterocolitis secondary to Clostridium difficile.

• Intussuszeption bei Säuglingen.

Campylobacteriosis treatment and management¹

The basis of management is rehydration. Assess for features of rehydration or shock and, where present, consider hospital admission. This is not usually required for campylobacteriosis.

Rehydrierung

This can usually be achieved by the oral route but, in more severe cases of campylobacteriosis, intravenous fluids may be needed. Age-specific information on advice regarding rehydration is covered in the separate Gastroenteritis in Adults and Older Children and Gastroenteritis in Children articles.

Antimotilitätsmittel

Sie sollten nicht routinemäßig eingesetzt werden, können aber bei Erwachsenen gelegentlich in Betracht gezogen werden:

• die zur Arbeit zurückkehren oder an einer besonderen Veranstaltung teilnehmen müssen.

• die Schwierigkeiten haben, die Toilette schnell zu erreichen.

• Wer reisen muss.

Wenn Loperamid verwendet wird, ist es das Antimotilitätsmittel der Wahl. Es sollte nicht verwendet werden, wenn die Merkmale auf eine mögliche Differentialdiagnose von:

• Dysenterie

• E. coli 0157

• Shigella

• Entzündliche Darmerkrankung

• Pseudomembranöse Kolitis

Antibiotika

Antibiotic treatment is not usually required for campylobacteriosis, as most cases are self-limiting.

If:

• Symptoms are severe - high fever, blood in stools or more than eight stools per day.

• There is immune compromise.

• Symptoms are worsening.

• Diarrhoea has lasted for more than a week.

Consider early prescribing with clarithromycin 250-500 mg twice daily for 5-7 days, within three days of onset of illness.

Antibiotic resistance is known to be increasing¹¹ .

Lactobacilli and probiotics may have a place in the prevention and treatment of campylobacteriosis and other forms of gastroenteritis. Further studies are needed before recommendations may be made. See the separate Probiotics and Prebiotics article.

Verhinderung der Ausbreitung von Infektionen

For work or school the exclusion period should be 48 hours from the last episode of diarrhoea.

Advise about other hygiene methods to help prevent spread such as:

• Sorgfältiges Händewaschen (nach dem Toilettengang, vor der Zubereitung von Mahlzeiten oder dem Essen, nachdem man einem Kind oder einer älteren Person bei der Selbstreinigung nach Durchfall geholfen hat usw.).

• Keine gemeinsame Nutzung von Handtüchern und Waschlappen.

• Waschen von verschmutzter Bettwäsche und Kleidung bei 60°C oder höher.

• Cleaning and disinfecting toilet seats, flush handles, taps and bathroom door handles regularly

Komplikationen¹

• Es kann zu Dehydrierung und Elektrolytstörungen kommen. Gelegentlich kann dies, wenn es nicht behoben wird, tödliche Folgen haben. Bei Säuglingen, älteren Menschen und immungeschwächten Personen ist die Wahrscheinlichkeit größer, dass sie schwerer erkranken und zur Rehydrierung in ein Krankenhaus eingeliefert werden müssen. Schwangere Frauen sind ebenfalls stärker dehydrierungsgefährdet.

• Zu den ungewöhnlichen Komplikationen gehören das hämolytisch-urämische Syndrom und die thrombotische thrombozytopenische Purpura.

• Other rare complications include Guillain-Barré syndrome and reactive arthritis.

• Das toxische Megakolon ist eine seltene, aber schwere Komplikation.

• Acute bacterial gastroenteritis has been linked with the onset of irritable bowel syndrome (IBS) symptoms in approximately 15% of patients¹² . These cases have been called postinfectious IBS. Campylobacter spp. is commonly associated with postinfectious IBS, as are E. coli O157, Salmonella spp. and Shigella spp.

• Schwere Durchfälle können die Aufnahme von Medikamenten beeinträchtigen, die für die Kontrolle chronischer Krankheiten erforderlich sind.

Prognose

The campylobacteriosis is usually self-limiting. Occasionally, death may occur from dehydration in the elderly and vulnerable, especially if immunocompromised. C. jejuni can produce bacteraemic illness in people with AIDS.

Campylobacteriosis prevention

Prevention requires measures at all stages of the food chain, from agricultural production to domestic preparation of food. National strategies include ongoing research, reduction of Campylobacter spp. prevalence at the food source, reduction of cross-contamination with other food products, control of imported sources, water treatment, etc.

Heating by cooking destroys Campylobacter spp., so at a domestic level adequate cooking of meat (particularly poultry) prevents infection. Uncooked meats should be kept separately from cooked and ready-to-eat foods in order to avoid cross-contamination. Hands should be washed after handling raw meat.

Other precautions the general public can take include:

• Milk should be pasteurised and drinking water chlorinated. When travelling to areas where tap water has not been treated to make it safe to drink, water should be boiled and/or sterilised. Ice cubes made from tap water should be avoided, as should salad washed in tap water.

• Those who are ill should not prepare or handle food.

• Cutting boards for cooked and uncooked meats and knives and other utensils must be kept apart.

• Hands should be washed before handling different food items, before eating or drinking, after going to the toilet and also after contact with animals, particularly pets and their bedding.

• Infected healthcare workers should not work. Antibiotics may reduce spread by curtailing the duration of excretion.